Tetrahedron letters2022，Vol.984.DOI:10.1016/j.tetlet.2022.153812

Cynotofuranoside A-C: Uncommon C21-steroidal furanosides derived from the acid hydrolysate of Cynanchum otophyllum roots

Li, Xiao-San Long, Juan Chen, Mei-Fang Wang, Qi-Lin Liang, Xiao-Yan Zheng, Jia-Chon Xing, Rui Yang, Xue-Mei Huang, Yong-Mei Luo, Hui
Tetrahedron letters2022，Vol.984.DOI:10.1016/j.tetlet.2022.153812
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  • NSTL
  • Elsevier

Cynotofuranoside A-C: Uncommon C21-steroidal furanosides derived from the acid hydrolysate of Cynanchum otophyllum roots

Li, Xiao-San 1Long, Juan 1Chen, Mei-Fang 1Wang, Qi-Lin 1Liang, Xiao-Yan 1Zheng, Jia-Chon 1Xing, Rui 1Yang, Xue-Mei 1Huang, Yong-Mei 1Luo, Hui1
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作者信息

  • 1. Guangdong Med Univ
  • 折叠

Abstract

Cynotofuranoside A-C (1-3), three previously undescribed C21-steroidal furanosides were isolated from the acid hydrolysate of Cynanchum otophyllum roots. Their structures were elucidated by extensive spectroscopic analysis including UV, IR, 1D and 2D NMR and HR-ESI-MS. Compounds 1-3 represented the first examples of 2,6-dideoxy-aldohexose in the form of furan ring attaching to 3b-OH of natural occurring C21-steroidal aglycones. The cytotoxicity of these compounds against human cancer MCF-7, HCT-116, HeLa, and HepG2 cells were evaluated. Compounds 1 and 3 showed moderate cytotoxic activities against HepG2 cancer cells with IC50 values of 43.15 and 34.36 mu M, respectively. (c) 2022 Elsevier Ltd. All rights reserved.

Key words

Cynanchum otophyllum/Acid hydrolysate/C 21-steroidal furanosides/Cytotoxicity/C-21 STEROIDAL GLYCOSIDES/PREGNANE GLYCOSIDES

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
参考文献量17
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