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New derivatives of tenvermectins through biotransformation as potential insecticides

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  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropeTenvermectins (TVMs) belongs to the 16-membered macrolactone family antibiotics with attractive insecticidal properties. In order to discover more potent TVM derivatives, microbial transformation of TVM-A and TVM-B by Penicilium griseofulvum CICC 40293 and Bacillus subtilis ATCC 6633 were investigated and offered us six new metabolites (1-5, 7) with regioselectivity, especially rare glycosuccinylated products, in addition to two known compounds (6, 8). Their chemical structures were well characterized via HR-ESI-MS and 1D/2D NMR spectra. All these metabolites exhibited good acaricidal and nematicidal activities against Tetranychus cinnabarinus and Bursaphelenchus xylophilus. These results indicated that the metabolites 1-8 can serve as potential leads for future development of new insecticides.

Acaricidal activityBiotransformationInsecticideNematicidal activityTenvermectins

Ge H.、Zhang S.、Guo H.、Qi H.、Wang R.、Zhang L.、Wang J.、Xiang W.

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Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province College of Life Science Huzhou University

Research Center of Life Science and Biotechnology School of Life Science Northeast Agricultural University

2022

10.1016/j.phytol.2022.02.004

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.49
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