首页|Corticosteroid Receptors in Cardiac Health and Disease
Corticosteroid Receptors in Cardiac Health and Disease
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Nuclear receptors play a central role in both energy metabolism and cardiomyocyte death and survival in the heart. Recent evidence suggests they may also influence cardiomyocyte endowment. Although several members of the nuclear receptor family play key roles in heart maturation (including thyroid hormone receptors) and cardiac metabolism, here, the focus will be on the corticosteroid receptors, the glucocorticoid receptor (GR) and mineralo-corticoid receptor (MR). The heart is an important target for the actions of corticoste-roids, yet the homeostatic role of GR and MR in the healthy heart has been elusive. However, MR antagonists are important in the treatment of heart failure, a condition associated with mitochondrial dysfunction and energy failure in cardiomyocytes leading to mitochondria-initiated cardiomyocyte death (Ingwall and Weiss, Circ Res 95:135-145, 2014; Ingwall , Cardiovasc Res 81:412-419, 2009; Zhou and Tian , J Clin Invest 128:3716-3726, 2018). In contrast, animal studies suggest GR activation in cardiomyocytes has a cardioprotective role, including in heart failure.
Heart failureGlucocorticoidCorticosteroidCardiomyocyteDOHAD (developmental origins of health and disease)Fetal programmingPreterm birthAntenatal corticosteroids
Jessica R. Ivy、Gillian A. Gray、Megan C. Holmes、Martin A. Denvir、Karen E. Chapman
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University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, The
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