首页|Hemorheological alterations of red blood cells induced by 450-nm and 520-nm laser radiation
Hemorheological alterations of red blood cells induced by 450-nm and 520-nm laser radiation
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NSTL
Elsevier
Proper rheological properties of red blood cells (RBC) including flexibility and aggregability are essential for healthy blood microcirculation. Excessive RBC aggregation has been observed to be associated with many pathological conditions and is crucial in acute circulatory problems. Low-level laser radiation (LLLR) has been found to have positive effects on the rheology of human blood, however, the detailed mechanisms of blood photobiomodulation remains unclear. In this study, utilizing the single-cell technique optical tweezers (OT) and traditional light microscopy, the influence of photobiomodulation of human RBC was examined under different conditions of laser irradiation. The results revealed that high radiant exposure (over 170.5 J/cm(2) radiant fluence) caused enhanced RBC aggregation and cell shape transformation while the aggregation force between single RBC remained unchanged. LLLR with radiant fluence below 9.5 J/cm2 by 450 nm wavelength improved the RBC deformability, weakened the strength of cell-cell interaction in the RBC disaggregation process, and showed rejuvenating effects on RBC suspended in a harsh cell environment.
Red blood cellsLow-level laser radiationBiomodulationAggregationDeformationOptical tweezersRHEOLOGICAL FACTORSAGGREGATIONIRRADIATIONDEFORMABILITYHEMOGLOBINPLASMA
Zhu, Ruixue、Avsievich, Tatiana、Su, Xinyang、Bykov, Alexander、Popov, Alexey、Meglinski, Igor
NSTL
Elsevier
