首页|Novel heteroborospherene as drug delivery systems for favipiravir drug: Ab-initio study
Novel heteroborospherene as drug delivery systems for favipiravir drug: Ab-initio study
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NSTL
Elsevier
The present paper evaluates pristine C4B32 borospherene and borospherenes functionalized with amino acid in drug delivery performance through density functional theory (DFT). Pristine and alanine-modified C4B32 clusters were found to have high drug delivery performance by designing borospherenes through the quadruple carbon atom doping of C4B32. The present work primarily sought to measure the interaction of borospherenes (both pristine and alanine-modified variants) and the favipiravir drug (FP). It was found that amino acid enabled a biodrug delivery function and improved the absorption of FP onto C4B32. Ultraviolet-visible (UV-Vis) spectroscopy was carried out, revealing a redshift in the drug@cluster electronic spectra toward higher wavelengths. The alanine-modified borospherene was found to have excellent drug delivery performance.
NSTL
Elsevier
