首页|Fabrication, in vitro and in vivo properties of β-TCP/Zn composites
Fabrication, in vitro and in vivo properties of β-TCP/Zn composites
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NSTL
Elsevier
? 2022 Elsevier B.V.In recent years, biodegradable Zn-based materials became a hopeful approach for new generation biomedical implants due to their acceptable mechanical performance, moderate biodegradation rate, and good biocompatibility. In this study, the combination of high-energy planetary milling and spark plasma sintering process were employed to fabricate n vol% β-TCP (n = 0, 0.5, 1, 3, 5, 10)/Zn composites with uniform microstructure and high relative density. The microstructure investigation, mechanical performance, degradation behavior, in vitro and in vivo properties of the composites were systematically investigated. As a result, β-TCP nanoparticles were homogeneously dispersed in the whole composites and possessed a good bonding interface with the Zn matrix. The degradation of pure Zn and β-TCP/Zn composites in vitro and vivo is a uniform corrosion process. Enhanced corrosion resistance attributed to the addition of β-TCP with a optimized content. The evaluation of osteogenic differentiation process showed that the addition of β-TCP induced the up-regulated expression of osteogesis-related genes (ALP) in mouse preosteoblasts, thus improving the osteogenic ability. As revealed by animal experiments, six months after implantation of pure Zn and 3TCP/Zn components, the blood biochemical parameters of rats showed no obvious tissue inflammation, indicating excellent in vivo biocompatibility of experimental materials. Histological investigation showed that with prolonged implantation time, the 3TCP/Zn components were more effective than pure Zn in promoting new bone formation. In summary, 3TCP/Zn matrix components developed in the present study should be useful for orthopedic implants.
Beta-tricalcium phosphateIn vitro degradationIn vivo animal modelOsteogenic capabilityZn matrix composite
Zhang Z.、Sun X.、Liu D.、Chen Z.、He X.、Li X.
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School of Materials Science and Engineering Tianjin University of Technology
National Demonstration Center for Experimental Function Materials Education Tianjin University of Technology
Department of General Surgery Tianjin Medical University General Hospital
NSTL
Elsevier
