首页|Antiosteosarcoma effects of novel 23-nor-3,4-seco-3-acetallupane triterpenoids from Acanthopanax gracilistylus W.W. Smith var. gracilistylus in 143B cells
Antiosteosarcoma effects of novel 23-nor-3,4-seco-3-acetallupane triterpenoids from Acanthopanax gracilistylus W.W. Smith var. gracilistylus in 143B cells
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NSTL
Elsevier
? 2022 Elsevier B.V.Three unprecedented 23-nor-3,4-seco-3-acetallupane triterpenoids, gracilistylacid A-C (1–3), along with three known lupanoids (4–6), were isolated from the aerial parts of Acanthopanax gracilistylus W.W. Smith var. gracilistylus. Compounds 1–3 may be biosynthetically formed via carboxylation, decarboxylation, cycloreversion, and aldolization reactions based on impressic acid (4). The structures of all compounds were characterized by spectroscopic techniques and X-ray craystallographyic studies. Compounds 3 and 4 exerted anti-osteosarcoma effects through an inhibition of cell migration and vasculogenic mimicry (VM) formation in 143B cells in vitro.
23-nor-34-seco-3-AcetallupanoidsAcanthopanax gracilistylus W. W. Smith var. gracilistylusMigrationVM formation
Li Z.、Zhang C.、Yang Z.、Yao N.、Liu H.、Zhou J.、Li S.、Qian S.
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School of Traditional Chinese Pharmacy China Pharmaceutical University
Country Institute of Basic Medical Science of Xiyuan Hospital China Academy of Chinese Medical Science
Department of Pharmaceutical Analysis & Metabolomics Jiangsu Province Academy of Traditional Chinese Medicine
NSTL
Elsevier
