首页|Sweat testing in the modern era: A national survey of sweat testing practice in the Republic of Ireland
Sweat testing in the modern era: A national survey of sweat testing practice in the Republic of Ireland
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NSTL
Elsevier
? 2021Background: The sweat test has been the "gold standard" diagnostic test for cystic fibrosis for more than 40 years. We hypothesized that there would be a change in the pattern of sweat testing in Ireland since the introduction of cystic fibrosis newborn screening in 2011, when practices were last reviewed. This is a follow up survey looking at sweat testing numbers and practices. Methods: A national survey compiled data on sweat collection, conductivity and sweat chloride testing in all hospitals previously identified as performing sweat tests. Results: All 13 centres in Ireland performing sweat testing in 2018 responded to the survey (100% return rate). Our results indicate that 1007 sweat tests were performed in 2018 compared to 2555 in 2011, equating to a 61% reduction. Seven out of 13 centres are performing less than 50 sweat tests per year. Nine out of 13 centres (69%) had a sweat test failure rate greater than the recommended allowable rate of ≤ 10%. We detected a trend of sweat testing in patients with an existing diagnosis of CF who had commenced cystic fibrosis transmembrane conductance regulator (CFTR) modulators. Conclusions: There has been a significant reduction in the number of sweat tests performed in Ireland since the introduction of newborn screening for CF. There remains a lack of standardisation in many aspects of the service ranging from sample collection to reporting of results. We have identified a new trend of sweat testing in the cystic fibrosis transmembrane conductance regulator modulator era.
Cystic fibrosisNational surveyNewborn screeningQuantity not sufficientSweat testing
Maguire B.、Blake O.、Boran G.、Borovickova I.、Abdelfadil S.、Murray C.、Elnazir B.、Linnane B.
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University of Dublin Trinity College
University Hospital Limerick
Children's Health Ireland at Temple Street and Crumlin Hospitals
Tallaght University Hospital
School of Medicine and Centre for Interventions in Infection Inflammation and Immunity (4i
NSTL
Elsevier
