首页|In vitro and ex vivo activity of an Azadirachta indica A.Juss. seed kernel extract on early sporogonic development of Plasmodium in comparison with azadirachtin A, its most abundant constituent

In vitro and ex vivo activity of an Azadirachta indica A.Juss. seed kernel extract on early sporogonic development of Plasmodium in comparison with azadirachtin A, its most abundant constituent

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  • NSTL
  • Elsevier
Background: NeemAzal((R)) (NA) is a quantified extract from seed kernels of neem, Azadirachta indica A. Juss. (Meliaceae), with a wide spectrum of biological properties, classically ascribed to its limonoid content. NA contains several azadirachtins (A to L), azadirachtin A (AzaA) being its main constituent. AzaA has been shown to inhibit microgamete formation of the rodent malaria parasite Plasmodium berghei, and NA was found to completely inhibit the transmission of Plasmodium berghei to Anopheles stephensi mosquitoes when administered to gametocytemic mice at a corresponding AzaA dose of 50 mg/kg before exposure to mosquitoes.

NeemAzal((R))Azadirachtin APharmacodynamicsExflagellationPlasmodium

Christophides, George、Lupidi, Giulio、Bramucci, Massimo、Quassinti, Luana、Esposito, Fulvio、Dahiya, Nisha、Chianese, Giuseppina、Abay, Solomon Mequanente、Taglialatela-Scafati, Orazio、Habluetzel, Annette、Lucantoni, Leonardo

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Imperial Coll London, Dept Life Sci, London, England

Univ Camerino, Sch Pharm, Piazza Costanti, I-62032 Camerino, MC, Italy

Univ Naples Federico II, Dept Pharm, Via Montesano 49, I-80131 Naples, Italy

2016

10.1016/j.phymed.2016.10.019

Phytomedicine

Phytomedicine

SCI
ISSN：0944-7113
年,卷(期)：2016.23(14)
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