Cucurbitane-type triterpenoids from the vines of Momordica charantia and their anti-inflammatory, cytotoxic, and antidiabetic activity

Liaw, Chia-Ching ¹Huang, Hung-Tse ¹Liu, Hui-Kang ¹Lin, Yu-Chi ¹Zhang, Li-Jie ¹Wei, Wen-Chi ¹Shen, Chien-Chang ¹Wu, Chia-Lun ¹Huang, Chung-Yi ²Kuo, Yao-Haur¹

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作者信息

1. Natl Res Inst Chinese Med
2. Natl Ilan Univ
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Abstract

Phytochemical investigation of the ethanol extract from wild Momordica charantia vines has resulted in isolation of seven cucurbitane-type triterpenoids, including six undescribed compounds, kuguaovins H.M, and the known compound, momordicoside K. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR, and MS experiments. The chemical structure of momordicoside K was determined for the first time by X-ray crystallographic analysis and its absolute configuration assigned. The cytotoxicity against four human tumor cell lines and anti-inflammatory activities on LPS-stimulated RAW264.7 macrophages were evaluated. Of the isolates, kaguaovin L exhibited potential cytotoxicity against MCF-7, HEp-2, Hep-G2, and WiDr cancer cell lines and showed moderate anti-NO production activity. In addition, kuguaovins H and J also showed the stimulatory effect of GLP-1 secretion on the murine intestinal secretin tumor cell line (STC-1).

Key words

Momordica charantia/Cucurbitaceae/Cucurbitane-type triterpenoids/Kuguaovins/Cytotoxicity/Anti-inflammatory activity/GLP-1 secretion/ANTI-HIV/FRUITS/GLYCOSIDES/SYSTEM/MAP30

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出版年

2022

Phytochemistry

CCR

ISSN：0031-9422

被引量1

参考文献量29

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