首页|Improved blood pressure and flow‐mediated dilatation via increased plasma adropin and nitrate/nitrite induced by high‐intensity interval training in patients with type 2 diabetes

Improved blood pressure and flow‐mediated dilatation via increased plasma adropin and nitrate/nitrite induced by high‐intensity interval training in patients with type 2 diabetes

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  • Wiley
New Findings What is the central question of this study? Exercise training increases adropin and nitrite/nitrate (NOx) plasma levels in middle‐aged and older healthy people. We hypothesized that high‐intensity interval training may improve blood pressure and flow‐mediated dilatation through the effects of adropin and NOx in patients of this age with type 2 diabetes. What is the main finding and its importance? High‐intensity interval training may be more effective than moderate‐intensity continuous training in improving endothelial function, blood pressure and flow‐mediated dilatation through its effects on adropin and NOx in patients with type 2 diabetes. Abstract Adropin is a newly identified bioactive protein that is important in energy hemostasis and vascular endothelial function. Lower levels of adropin in patients with type 2 diabetes are related to coronary atherosclerosis, characterized by impaired flow‐mediated dilatation (FMD). The purpose of the present study was to investigate FMD and plasma levels of adropin and nitrite/nitrate (NOx) in patients with type 2 diabetes at baseline and follow‐up after 12?weeks of high‐intensity interval training (HIIT) or moderate‐intensity continuous training (MICT). Sixty‐six persons with type 2 diabetes were divided into HIIT, MICT, and control groups. The HIIT group intervention was 12 intervals (1.5?min) at 85–90% maximal heart rate (HRmax) separated by 2?min at 55–60% HRmax in three sessions per week for 12?weeks. MICT training consisted of 42?min of cycling at 70% HRmax. Before and after the intervention, FMD was recorded with high‐resolution Doppler ultrasound. Plasma levels of adropin and NOx were measured by enzyme‐linked immunosorbent assay. After training FMD was significantly higher in the MICT and HIIT groups compared to the control group (P?<?0.05). Plasma levels of adropin and NOx were higher in both exercise groups, but the increase was greater in the HIIT group (P?<?0.01). Peak oxygen consumption was increased after exercise training in both groups compared to the control group (P?<?0.01). Percentage FMD showed a positive correlation with plasma levels of adropin and NOx (both P?<?0.01), and a negative correlation with diastolic blood pressure (r?=??0.530, P?=?0.035) and systolic blood pressure (r?=??0.606, P?=?0.013) in the HIIT group. The results indicate that HIIT improved FMD whilst increasing adropin, NOx and peak oxygen consumption. Increased plasma levels of adropin may contribute, in part, to blood pressure reduction by increasing nitric oxide production.

adropinflow‐mediated dilatationhigh‐intensity interval trainingNOxtype 2 diabetes

Mohsen Davoodi、Behnam Keshtkar Hesamabadi、Erfaneh Ariabood、Mohammad Reza Izadi、Alireza Ghardashi‐Afousi、Mohammad Ali Babaee Bigi、Maryam Asvadi‐Fard、Abbas Ali Gaeini

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Shiraz University of Medical Science

DANA Brain Health Institute,Irainian Neuroscience Society‐Fars Chapter

Department of Exercise Physiology,University of Shahid Chamran

Department of Physical Education and Sport Science,Imam Hossein Comperhensive University

Department of Exercise Physiology,University of Tehran

Cardiovascular Research Center,Shiraz University of Medical Science

Department of Medicine,Iran University of Medical Science

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2022

10.1113/EP089371

Experimental physiology.

Experimental physiology.

ISSN：0958-0670
年,卷(期)：2022.107(8)
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