首页|Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases
Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases
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NSTL
Astaxanthin (AST) is a red pigmented carotenoid with significant antioxidant， anti-inflammatory， anti-prolifer-ative， and anti-apoptotic properties。 In this study， we summarize the available literature on the anti-inflammatory efficacy of AST in various chronic and acute disorders， such as neurodegenerative， renal-， hep-ato-， skin- and eye-related diseases， as well as gastrointestinal disorders。 In addition， we elaborated on therapeutic efficacy of AST and the role of several pathways， including PI3K/AKT， Nrf2， NF-κB， ERK1/2， JNK， p38 MAPK， and JAK-2/STAT-3 in mediating its effects。 However， additional experimental and clinical studies should be performed to corroborate the anti- inflammatory effects and protective effects of AST against inflammatory diseases in humans。 Nevertheless， this review suggests that AST with its demonstrated anti-inflammatory property may be a suitable candidate for drug design with novel technology。
NSTL
