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Euphane and friedelane triterpenoids from Tripterygium wilfordii

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  • NSTL
  • Elsevier
? 2021 Phytochemical Society of EuropeFour hitherto unknown triterpenoids, including one euphane, namely wilfordeuphone (1), and three friedelanes, namely wilforic acids G ? I (2–4), were isolated from the ethanol extract of the roots of Tripterygium wilfordii. The absolute configuration of 1 was established by single crystal X-ray diffraction. In addition, this study is the first to report euphane-type triterpenoid in the genus Tripterygium. Compound 1 exhibited the moderate cytotoxic activity when evaluated against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480), with IC50 values ranging from 14.0–26.7 μM.

EuphaneFriedelaneSingle crystal X-ray diffractionTripterygium wilfordiiTriterpenoid

Li X.-M.、Yang C.-M.、Zhang L.-N.、Jiang X.-J.、Wei G.-Z.、Wang F.

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BioBioPha Co. Ltd.

2022

10.1016/j.phytol.2021.10.016

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.47
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