首页|Inhibition of PD-L1-mediated tumor-promoting signaling is involved in the anti-cancer activity of p-tocotrienol
Inhibition of PD-L1-mediated tumor-promoting signaling is involved in the anti-cancer activity of p-tocotrienol
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NSTL
Programmed death-ligand 1 (PD-L1)， a critical immune checkpoint ligand， is commonly overexpressed on the surface of many tumor types including lung and prostate cancer。 PD-L1 can exert cancerpromoting activity through either suppressing T cell-mediated immune response or activating tumor-intrinsic signaling。 Here， we demonstrated that β-tocotrienol (P-T3)， an isomer of vitamin E， effectively inhibited PD-L1 expression both in vitro and in vivo， which was mechanistically associated inactivating JAK2/STAT3 pathway。 Down-regulating PD-L1 expression by P-T3 led to enhanced immune response and inactivation of PD-L1-induced tumor-intrinsic signaling， which in turn contributed to its anticancer activity。 This study uncovered a novel mechanism involved in the anticancer effect of P-T3。
NSTL
