首页|Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells

Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells

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  • NSTL
  • Elsevier
A new isoform of human manganese superoxide dismutase (SOD) has been recently isolated and obtained in a synthetic recombinant form and termed rMnSOD. As compared to other SODs, this isoform exhibits a dramatically improved cellular uptake and an intense antioxidant and antitumoral activity. Unfortunately, its use is severely hampered as this active pharmaceutical ingredient (API) in solution suffers from remarkable instability, which realizes as an interplay of unfolding and aggregation phenomena. This leads the API to be ineffective after three weeks only when stored at 4 degrees C.

Superoxide dismutaseCancer cellsAntiproliferative effectProtein stabilityNanocarrierLayer-by-layer depositionNanofabrication

Russo, Giacomo、Iaccarino, Giulia、Piccolo, Marialuisa、Ferraro, Maria Grazia、Vecchione, Raffaele、Grumetto, Lucia、Netti, Paolo A.、Santamaria, Rita

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Edinburgh Napier Univ, Sch Appl Sci, Sighthill Campus,9 Sighthill Ct, Edinburgh EH11 4BN

Ist Italian Tecnol, Ctr Adv Biomat Hlth Care CRIB, Largo Barsanti & Matteucci 53, I-80125 Naples

Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Biochem Lab, Via D Montesano 49, I-80131

Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Pharm Anal & Biopharm Lab, Via D Montesano 49

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2021

10.1016/j.ejps.2021.105825

European journal of pharmaceutical sciences

European journal of pharmaceutical sciences

ISTP
ISSN：0928-0987
年,卷(期)：2021.162
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