Papiliomyces sp. was found in 2020, and its secondary metabolites have never been reported. Papililone A (1), a new tetracyclic diterpenoid with an unprecedented 5/5/5/6 ring system, was isolated from Papiliomyces sp. under the guidance of HPLC-MS/MS investigation. This structure was assigned by detailed spectroscopic analysis, calculated electronic circular dichroism, and computer-assisted structure elucidation. Moreover, 1 exhibited moderate inhibitory activity against lipopolysaccharide induced nitric oxide production in RAW264.7 cells with IC50 value of 30.9 +/- 1.52 mM. (C) 2022 Elsevier Ltd. All rights reserved.
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