首页|Three new jatrophane diterpenoids from Euphorbia peplus Linn. with activity towards autophagic flux
Three new jatrophane diterpenoids from Euphorbia peplus Linn. with activity towards autophagic flux
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NSTL
Elsevier
? 2022 Phytochemical Society of EuropeThree undescribed jatrophane diterpenoids, named euphpepluones P-R (1–3), were isolated from the whole plant Euphorbia peplus. The structures of these compounds were elucidated by spectroscopic methods. The absolute configuration of 1 was further assigned by X-ray crystallographic analysis. All compounds were evaluated for bioactivity towards autophagic flux by flow cytometry using HM mCherry-GFP-LC3 cells. Compounds 2 and 6 exhibited significant inhibition of autophagic flux.
Pu X.-X.、Li J.-C.、Guan S.-P.、Hao X.-J.、Di Y.-T.、Lu Q.-Y.、Li Y.-Y.、Cao M.-M.、Ran X.-Q.、Luo R.-C.、Liu J.、Yan Y.
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School of Chinese Materia Medica Yunnan University of Traditional Chinese Medicine
State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology Chinese Academy of Sciences
CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences
Guizhou Chemical Drug Research and Development Engineering Technical Center Guizhou Medicinal University
NSTL
Elsevier
