首页|Morphological Changes in GABAergic Structures of the Rat Brain during Postnatal Development
Morphological Changes in GABAergic Structures of the Rat Brain during Postnatal Development
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NSTL
Springer Nature
The aim of the study was to investigate brain GABAergic neurons and synaptic terminals in early postnatal development and aging. Wistar rat brain slices at different stages of postnatal development (from postnatal day 7 to 24 months) were used. Immunohistochemical staining of GABA synthesizing enzyme (glutamate decarboxylase isoform 67 or GAD67) was performed to reveal GABAergic structures. We described morphological changes that occur in the GABAergic system during postnatal development. In particular, it has been shown that synaptic terminals are predominantly localized in cortical layer 1 in 7-day-old animals. Our findings suggest that Cajal-Retzius cells are not GABAergic. GABAergic neurons were found in young and old animals in the subventricular zone. We found that the epithelial layer of choroid plexus contains GAD67 by the end of the first month of postnatal development. In this regard, these epithelial cells may be a source of extrasynaptic GABA, which enters the cerebrospinal fluid and then nervous tissue of the brain.
NSTL
Springer Nature
