首页|Synthesis of cinnamic acid ester derivatives with antiproliferative and antimetastatic activities on murine melanoma cells
Synthesis of cinnamic acid ester derivatives with antiproliferative and antimetastatic activities on murine melanoma cells
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NSTL
Melanoma is the most aggressive skin cancer, and its incidence has continued to rise during the past decades. Conventional treatments present severe side effects in cancer patients, and melanoma can be refractory to commonly used anticancer drugs, which justify the efforts to find new potential anti-melanoma drugs. An alternative to promote the discovery of new pharmacological substances would be modifying chemical groups from a bioactive compound. Here we describe the synthesis of seventeen compounds derived from cinnamic acid and their bioactivity evaluation against melanoma cells. The compound phenyl 2,3-dibromo-3-phenylpropanoate (3q) was the most effective against murine B16-F10 cells, as observed in cytotoxicity and cell migration assays. Simultaneously, this compound showed low cytotoxic activity on non-tumor cells. At the highest concentration, the compound 3q was able to trigger apoptosis, whereas, at lower concentrations, it affected the cell cycle and melanoma cell proliferation. Furthermore, cinnamate 3q impaired cell invasion, adhesion, colonization, and actin polymerization. In conclusion, these results highlight the antiproliferative and antimetastatic potential of cinnamic acid derivatives on melanoma.
Cinnamic acidCinnamatesAnticancer drug discoveryAnti-melanomaAntitumoral activityB16-F10 cell line
Juliana Alves do Vale、Michelle Peixoto Rodriguesb、Angela Maria Almeida Lima、Samira Soares Santiago、Graziela Domingues de Almeida Lima、Alisson Andrade Almeida、Lero Licursi de Oliveira、Gustavo Costa Bressan、Robson Ricardo Teixeira、Mariana Machado-Neves
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Department of General Biology, Federal University of Vi?osa, Vi?osa, Minas Gerais, Brazil
NSTL
