首页|Isoprenylated chromones from the stems of Harrisonia perforata

Isoprenylated chromones from the stems of Harrisonia perforata

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  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropeThree new isoprenylated chromones, named harriforatins A?C (1?3), along with 13 known compounds (4?16) were isolated from the stems of Harrisonia perforata. Their planar structures were elucidated by spectroscopic measurements. The experimental and calculated ECD curves were used to determine their absolute configurations. Most isolated compounds were evaluated for inflammation inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Only compounds 5 and 6 showed inhibitory effects on NO production, with IC50 values of 42.8 and 47.0 μM, respectively, that were stronger than that of the positive control, indomethacin (IC50 = 68.6 μM).

Anti-inflammatory activityChromonesHarriforatinsHarrisonia perforateRutaceae

Injan N.、Maneerat T.、Laphookhieo S.、Rujanapun N.、Charoensup R.、Nokbin S.、Cheenpracha S.、Chokchaisiri R.、Ganranoo L.

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Division of Chemistry School of Science University of Phayao

Center of Chemical Innovation for Sustainability (CIS) and School of Science Mae Fah Luang University

Medicinal Plants Innovation Center of Mae Fah Luang University

Department of Chemistry Faculty of Science Kasetsart University

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2022

10.1016/j.phytol.2022.04.003

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.49
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