The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus
Vicic, Marijana 1Sotosek, Vlatka 2Brajac, Ines 1Kastelan, Marija 1Prpic-Massari, Larisa1
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作者信息
1. Univ Rijeka, Fac Med, Dept Dermatovenerol, Clin Hosp Ctr Rijeka, Kresimirova 42, Rijeka 51000
2. Univ Rijeka, Dept Anesthesia Resuscitat & Intens Care, Fac Med, Clin Hosp Ctr Rijeka, Tome Strizica
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Abstract
Lichen planus is a chronic mucocutanous disorder histopathologically characterized with a keratinocytes apoptosis, subsequent basal cell layer liquefaction and accumulation of the inflammatory infiltrate in papillary dermis. A formation of apoptotic bodies in basal cell layer is due to a cytotoxic lymphocyte attack to the basal keratinocytes. It has been demonstrated that the cytotoxic molecules included in this attack are perforin and granzyme B. Both molecules are found upregulated in CD8+ lymphocytes that are in close contact to keratinocytes. However, their amount is lower in lichen planus than in other skin disease characterized by liquefaction and vacuolar degeneration of the basal epidermal layer. This could speculate about other cytotoxic molecule such as granulysin that could mediate keratinocyte apoptosis. Therefore, in this article we hypothesize about the crucial role of granulysin molecule in keratinocytes killing that could contribute to a lichen planus pathogenesis.
NSTL
Elsevier