首页|Undiagnosed sleep disorder breathing as a risk factor for critical COVID-19 and pulmonary consequences at the midterm follow-up

Undiagnosed sleep disorder breathing as a risk factor for critical COVID-19 and pulmonary consequences at the midterm follow-up

扫码查看
原文链接
  • NSTL
  • Elsevier
Introduction: Patients with severe COVID-19 develops an acute respiratory distress syndrome (ARDS), requiring admission to the intensive care unit. COVID-19 also reports an increased prevalence of comorbidities, similar to patients with Sleep disorder breathing (SDB). Objectives: To evaluate the association between undiagnosed SDB and the risk of ARDS and pulmonary abnormalities in a cohort of patients' survivors of COVID-19 between 3 and 6 months after diagnosis. Methods: Prospective cohort study of patients who developed ARDS during hospitalization due to COVID-19 compared with a control group of patients who had COVID-19 with mild to moderate symptoms. All patients were evaluated between the 12th and 24th week after SARS-CoV-2 infection. The evaluation includes persistent symptoms, lung diffusing capacity of carbon monoxide (DLCO), chest CT scan and home sleep apnea test. SDB was diagnosed by the respiratory disturbance index > 5 ev/h. The association between SDB and ARDS, the hazards of lung impairment and the hazard ratios (HR) were analyzed. Results: A total of 60 patients were included (ARDS: 34 patients, Control: 26 patients). The mean follow-up was 16 weeks (range 12-24). ARDS reported a high prevalence of SDB (79% vs. 38% in control group). A total of 35% reported DLCO impairment, and 67.6% abnormal chest CT. SDB was independently associated to ARDS, OR 6.72 (CI, 1.56-28.93), p < 0.01, and abnormal Chest CT, HR 17.2 (CI, 1.68-177.4, p 1/4 0.01). Besides, ARDS, days in mechanical ventilation, male gender were also associated with an increased risk of abnormal chest CT. Conclusion: Undiagnosed SDB is prevalent and independently associated with ARDS. In addition, undiagnosed SDB increased the hazard of abnormal Chest CT in the midterm. (C) 2021 Elsevier B.V. All rights reserved.

COVID-19SARS-CoV-2Pulmonary function testSleep disorder breathingSleep apneaObstructiveCLINICAL-PRACTICE GUIDELINEACUTE RESPIRATORY SYNDROMEQUALITY-OF-LIFEAPNEASTATEMENTCAPACITYVALUESSCALE

Labarca, Gonzalo、Henriquez-Beltran, Mario、Rubilar, Daniel、Sanhueza, Rocio、Villanueva, Carolina、Horta, Gloria、Sanhueza, Felipe、Vasquez, Jaime、Melo, Pedro、Dreyse, Jorge、Llerena, Faryd、Erices, Gustavo、Lastra, Jaime、Enos, Daniel、Castillo, Daniela、Fraga, Marco、Lamperti, Liliana、Ormazabal, Valeska、Riffo, Benilde、Jorquera, Jorge、Fernandez-Bussy, Sebastian、Gonzalez, Jessica、Barbe, Ferran、Nova-Lamperti, Estefania

展开 >

Fac Med,Univ Concepcion

Escuela Kinesiol,Univ Santo Tomas

Internal Med,Hosp Reg Dr Guillermo Grant Benavente

Complejo Asistencial Dr Victor Rios Ruiz

Resp & Sleep Med Unit,Clin Las Condes

Fac Pharm,Univ Concepcion

PreveGen Clin Lab

Resp & Crit Care,Mayo Clin

Pulm Dept,Hosp Univ Arnau Vilanova & Santa Maria

展开 >

2022

10.1016/j.sleep.2021.02.029

Sleep medicine

Sleep medicine

SCI
ISSN：1389-9457
年,卷(期)：2022.91
  • 3
  • 32