首页|Anti-inflammatory abietanes diterpenes and triterpenoids isolated from Clinopodium polycephalum

Anti-inflammatory abietanes diterpenes and triterpenoids isolated from Clinopodium polycephalum

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  • NSTL
  • Elsevier
? 2022 Elsevier B.V.Two previously undescribed diterpenes (1 and 2), as well as one curious triterpenoid were isolated from Clinopodium polycephalum, a medicinal plant distributed in southwestern and eastern China. Their structures were elucidated using MS analyses, UV spectrum, and extensive 2D-homo and heteronuclear NMR data interpretations. Among them, 1 had an unusual skeletal characteristic produced by a rare methyl migration pathway. All monomer compounds exhibited inhibitory effects on NO production in LPS-induced RAW 264.7 cells without affecting cell viabilities, which were comparable to that of positive control.

Abietane diterpenoidsAnti-inflammatory activityClinopodium polycephalumTriterpenoids

Liu Y.、Song H.、Xu J.、Bi G.、Meng D.

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School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

2022

10.1016/j.fitote.2022.105244

Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
年,卷(期)：2022.161
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