首页|Generating adverse outcome pathway (AOP) of inorganic arsenic-induced adult male reproductive impairment via integration of phenotypic analysis in comparative toxicogenomics database (CTD) and AOP Wiki

Generating adverse outcome pathway (AOP) of inorganic arsenic-induced adult male reproductive impairment via integration of phenotypic analysis in comparative toxicogenomics database (CTD) and AOP Wiki

扫码查看
原文链接
  • NSTL
  • Elsevier
Background: Inorganic arsenic (iAs) is a worldwide environmental pollutant which exerts complicated and various toxic effects in organisms. Increasingly epidemic studies have revealed the association between iAs exposure and adult male reproductive impairment. Consistent with the proposal for toxicity testing in the 21st century (TT21C), the adverse outcome pathway (AOP) framework may help unravel the iAs-caused molecular and functional changes leading to male reproductive impairment.

Adverse outcome pathwayArsenicReproductionPhenotypeSystemic biology

Chai, Zili、Zhao, Chenhao、Jin, Yuan、Wang, Yimeng、Zou, Peng、Ling, Xi、Yang, Huan、Zhou, Niya、Chen, Qing、Sun, Lei、Chen, Wen、Ao, Lin、Cao, Jia、Liu, Jinyi

展开 >

Army Med Univ, Third Mil Med Univ, Key Lab Med Protect Electromagnet Radiat, Minist Educ China,Inst

Air Force Engn Univ, Informat & Nav Coll, Xian 710077, Peoples R China

Qingdao Univ, Sch Publ Hlth, Qingdao 266000, Peoples R China

Sun Yat Sen Univ, Sch Publ Hlth, Dept Toxicol, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou

展开 >

2021

10.1016/j.taap.2020.115370

Toxicology and Applied Pharmacology

Toxicology and Applied Pharmacology

SCI
ISSN：0041-008X
年,卷(期)：2021.411
  • 10
  • 61