首页|Ganoderma lucidum: A potential pleiotropic approach of ganoderic acids in health reinforcement and factors influencing their production

Ganoderma lucidum: A potential pleiotropic approach of ganoderic acids in health reinforcement and factors influencing their production

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  • NSTL
  • Elsevier
Ganoderma lucidum (G. lucidum) main attractive pharmacological characteristics are anti-tumor and immunomodulatory activities which are chiefly associated with its two prin-cipal bioactive compounds, those are polysaccharides and triterpenoids. Ganoderic acids (GAs) are one of the most discovered triterpenoids of G. lucidum among various triterpe-noids. The prominent medicinal mushroom G. lucidum possesses GAs as essential bioactive constituents that are highly oxygenated lanostane-type triterpenoids. GAs exhibit diverse potential action against numerous diseases such as anticancer, antioxidant, anti-inflammatory, anti-HIV, cardioprotective, antiallergic, antihepatotoxic, neuroprotective and antinociceptive properties. GAs act through different mechanisms that include cyto-toxic, apoptosis, inducing cell cycle arrest, inhibition of topoisomerases, antiproliferation, anti-invasion, inhibition of NF-kB AP1/uPA, farnesyl protein transferase and JAK-STAT3 pathway. The miraculous effects of GAs fascinate the researchers for their production. Various environmental factors such as biochemical signals, nutritional and physical that influence the biosynthesis of GA. However, the scarcities of pure compounds or accurately characterized extracts are the main problem of clinical studies. Substantial steps are required for characterized extracts of active compounds. This review contributes a thor-ough insight into the mode of actions of GAs and their possible reinforcements to over-come various diseases. (c) 2021 British Mycological Society. Published by Elsevier Ltd. All rights reserved.

CancerCytotoxicFermentationGanoderic acidsTriterpenoidsREISHI MEDICINAL MUSHROOMMITOCHONDRIA MEDIATED APOPTOSISINDUCED SECONDARY METABOLISMLANOSTANE-TYPE TRITERPENOIDSINHIBITS TUMOR INVASIONFED-BATCH FERMENTATIONSTATIC LIQUID CULTUREBREAST-CANCER CELLSFRUITING BODYIN-VITRO

Ahmad, Md Faruque、Wahab, Shadma、Ahmad, Fakhruddin Ali、Ashraf, Syed Amir、Abullais, Shahabe Saquib、Saad, Hisham H.

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Jazan Univ

King Khalid Univ

Al Hada & Taif Mil Hosp

Univ Hail

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2022

10.1016/j.fbr.2021.12.003

Fungal Biology Reviews

Fungal Biology Reviews

SCI
ISSN：1749-4613
年,卷(期)：2022.39
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