首页|Role of ionic liquids on stabilization of therapeutic proteins and model proteins

Role of ionic liquids on stabilization of therapeutic proteins and model proteins

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Ionic liquids (ILs) exhibit potential as excipients to stabilize proteins in solutions. This mini-review is not a detailed reference book on ILs, rather a brief overview of the main achievements published in the literature on their effect on protein aggregation, unfolding, structural and thermal stability, and activity. The main focus of the manuscript is three widely studied groups of ionic liquids: imidazolium-, cholinium- and alkylammonium-based and their effect on the model and therapeutic proteins.

Ionic liquidsProteinStabilityAggregationRefoldingStructurestorageREFOLDING ADDITIVESAMYLOID FORMATIONCYTOCHROME-CAQUEOUS-SOLUTIONSTABILITYAGGREGATIONCRYOPRESERVATIONDESTABILIZATIONDISSOLUTIONFORMULATION

Guncheva, Maya

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Inst Organ Chem,Bulgarian Acad Sci

2022

The protein journal

The protein journal

ISSN:1572-3887
年,卷(期):2022.41(3)
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