Fitoterapia2022，Vol.1567.DOI:10.1016/j.fitote.2021.105085

New iboga-type alkaloids from Ervatamia officinalis and their anti-inflammatory activity

Tang, Ben-qin Li, Zi-wei Li, Lin Li, Bao-jing Bian, Ya-qi Yu, Guo-dong Chang, Yu Lee, Simon Ming-yuen Zhang, Xiao-qi
Fitoterapia2022，Vol.1567.DOI:10.1016/j.fitote.2021.105085
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New iboga-type alkaloids from Ervatamia officinalis and their anti-inflammatory activity

Tang, Ben-qin 1Li, Zi-wei 2Li, Lin 3Li, Bao-jing 4Bian, Ya-qi 3Yu, Guo-dong 1Chang, Yu 2Lee, Simon Ming-yuen 3Zhang, Xiao-qi2
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作者信息

  • 1. Shunde Polytech
  • 2. Jinan Univ
  • 3. Univ Macau
  • 4. Yunnan Univ Chinese Med
  • 折叠

Abstract

Four new iboga-type alkaloids, ervaoffines H-K (1-4), along with five known compounds were obtained from the aerial parts of Ervatamia officinalis. The absolute configurations of 1-4 were confirmed by X-ray diffraction and electronic circular dichroism (ECD) analyses. The isolates were tested for their anti-inflammatory activity. Compounds 1, 5, 6, and 9 showed potential inhibitory effect of NO production in LPS-stimulated BV2 and RAW264.7 cells.

Key words

Ervatamia officinalis/Iboga-type alkaloids/Anti-inflammatory/Ervaoffines/NO release/MONOTERPENOID INDOLE ALKALOIDS

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出版年

2022
Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
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