首页|Altered White-matter Tract Property in Adults with Attention-deficit Hyperactivity Disorder
Altered White-matter Tract Property in Adults with Attention-deficit Hyperactivity Disorder
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Elsevier
Although altered microstructure properties of white-matter tracts have been reported in children with attention-deficit/hyperactivity disorder (ADHD), findings from relatively few adult ADHD studies are inconsistent. This study aims to examine microstructural property over the whole brain in adults with ADHD and explore struc-tural connectivities. Sixty-four medication-nax3ca;ve adults with ADHD and 81 healthy adults received diffusion spec-trum imaging. Generalized fractional anisotropy (GFA), an index indicating microstructural property, was calculated stepwise among 76 white-matter tracts. With the threshold-free clustering weighted method, the seg-ments with the largest group difference were selected, and mean GFA (mGFA) values were calculated. Adults with ADHD had increased mGFA values in the segments located in the left frontal aslant tract, the right inferior longi-tudinal fasciculus, and the left perpendicular fasciculus, and reduced mGFA values in the segments located in the right superior longitudinal fasciculus (SLF) I, the left SLF II, the right frontostriatal tracts from dorsolateral pre -frontal cortex and the ventrolateral prefrontal cortex, the right medial lemniscus, the right inferior thalamic radi-ation to the auditory cortex, and the callosal fibers. Additionally, the mGFA value of the right SLF I segment was associated with hyperactivity-impulsivity symptoms. Our findings suggest that white-matter tracts with altered microstructure properties are located within the attention networks, fronto-striato-thalamocortical regions, and those associated with attention and visual perception in adults with ADHD. (c) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.
NSTL
Elsevier
