首页|Antioxidant and antiglycating activities of Salvia sahendica and its protective effect against oxidative stress in neuron-like PC 12 cells
Antioxidant and antiglycating activities of Salvia sahendica and its protective effect against oxidative stress in neuron-like PC 12 cells
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NSTL
Springer Nature
Increased oxidative stress is widely accepted to be a factor in the development and progression of Alzheimer's disease (AD). Here we introduced Salvia sahendica as a protective agent in differentiated PC 12 cells, which are commonly considered to be a reliable model of neuronal cells. Our results demonstrated that S. sahendica has antioxidant and antiglycating properties in in vitro system and these properties are expanded into H_2O_2-induced model. S. sahendica inhibited H_2O_2-induced cell death in PC 12 cells. We further showed that this plant exerts its protective effect by increasing superoxide dismutase and catalase levels, reducing lipid peroxidation and upregulating hemoxygenase-1 and glutamylcysteine synthetase proteins. This study raises the possibility of developing S. sahendica as a potential neuroprotective agent.
NSTL
Springer Nature
