A NEW PHENOLIC GLYCOSIDE WITH ALDOSE REDUCTASE INHIBITORY ACTIVITY FROM Eucommia ulmoides

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外文摘要：A new phenolic glycoside 1 and three known compounds(2-4)have been isolated from the 95% ethanolic extract of Eucommia ulmoides Oliv.leaves.Their structures were identified as erythro-1-0-methyl-2-O-β-D-gIucopyranosyl-guaiacylglycerol(1),3,5-dimethoxybenzyl alcohol A-O-β-D-glucopyranoside(2),salidroside(3),and dihydroconiferin(4)from spectroscopic data(~1H NMR,~(13)C NMR,HSQC,and HMBC)and using chemical methods.In the in vitro assay,compound 1 displayed potent inhibitory activity against aldose reductase with an IC_(50)value of 7.82 μM.

外文关键词：

EucommiaceaeEucommia ulmoidesphenolic glycosidealdose reductase inhibition

作者：

Lin-Lin Liu、Jia Chen、Yang Liu

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作者单位：

Jiangsu Key Laboratory of Crop Genetics and Physiology/Co-Innovation Center for Modern Production Technology of Grain Crops,Yangzhou University,225009,Yangzhou,P.R.China

出版年：

2021

Химия природных соединений

ISSN：0023-1150

年,卷(期)：2021.(1)