首页|Patient-derived Tumour Organoids: A Bridge between Cancer Biology and Personalised Therapy
Patient-derived Tumour Organoids: A Bridge between Cancer Biology and Personalised Therapy
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NSTL
Elsevier
Patient-derived tumour organoids (PDOs) have revolutionised our understanding of cancer biology and the applications of personalised therapies. These advancements are principally ascribed to the ability of PDOs to consistently recapitulate and maintain the genomic, proteomic and morphological characteristics of parental tumours. Given these characteristics, PDOs (and their extended biobanks) are a representative preclinical model eminently suited to translate relevant scientific findings into personalized therapies rapidly. Here, we summarise recent advancements in PDOs from the perspective of cancer biology and clinical applications, focusing on the current challenges and opportunities of reconstructing and standar-dising more sophisticated PDO models.Statement of Significance Patient-derived tumour organoids (PDOs), three-dimensional (3D) self-assembled organotypic structures, have revolutionised our understanding of cancer biology and the applications of personalised therapies. These advancements are principally ascribed to the ability of PDOs to consistently recapitulate and main-tain the genomic, proteomic and morphological characteristics of parental tumours. Given these charac-teristics, PDOs (and their extended biobanks) are a representative preclinical model eminently suited to translate relevant scientific findings into personalized therapies rapidly. (c) 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
NSTL
Elsevier
