首页|Two new polycyclic polyprenylated acylphloroglucinols from Hypericum curvisepalum N. Robson

Two new polycyclic polyprenylated acylphloroglucinols from Hypericum curvisepalum N. Robson

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  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropePhytochemical investigation of the whole plant of Hypericum curvisepalum led to the isolation of nine polycyclic polyprenylated acylphloroglucinols (1–9). Among them, curvisepalumiones A (1) and B (2) are two new compounds and their structures were elucidated based on extensive spectroscopic data analysis combined with Rh2(OCOCF3)4-induced electronic circular dichroism experiment. Cytotoxic assay showed that all the tested compounds except for 1 was moderately cytotoxic against human hepatocarcinoma cell line SMMC-7721 cell line, while compounds 3 and 4 also exhibited cytotoxicity toward MGC-803 cells. In addition, compound 2 exhibited weak inhibitory activity against Bacillus subtilis.

Antibacterial activityCytotoxic activityHypericum curvisepalumPolycyclic polyprenylated acylphloroglucinols

Zhou Z.-B.、Zeng H.、Huang Y.-Y.、Wei X.、Teng L.-P.、Shi W.-P.、Pan K.

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School of Pharmacy Youjiang Medical University for Nationalities

Xinjiang Production & Construction Corps Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin Tarim University

State Key Laboratory of Natural Medicines School of Traditional Chinese Pharmacy China Pharmaceutical University

2022

10.1016/j.phytol.2022.01.015

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.48
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