首页|Spasmolytic, Gastroprotective and Antioxidant Activities of Dry Methanol Extract of Ferula heuffelii Underground Parts
Spasmolytic, Gastroprotective and Antioxidant Activities of Dry Methanol Extract of Ferula heuffelii Underground Parts
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NSTL
Wiley
Abstract Dry MeOH extract of Ferula heuffelii (Apiaceae) underground parts was tested for spasmolytic, gastroprotective and antioxidant activities. HPLC analysis revealed that chlorogenic acid (CGA; 34.6?mg/g) was its main constituent. Extract in?vitro exhibited notable total antioxidant activity (FRAP value=1.0 μmol Fe2+/mg), and scavenging of DPPH (SC50=62.5?μg/ml) and ?OH radicals (49.5?% at 20?μg/ml in 2‐deoxyribose assay). In vitro on isolated rat ileum, extract exhibited significant spasmolytic activity, i.?e., it showed 124.6?% of maximal atropine effect on spontaneous contractions (at 100?μg/ml), and reduced spasmogenic effect of KCl (80?mm) to 44.4?% (at 60?μg/ml) and of highest applied concentration of ACh to 26.3?% (at 120?μg/ml). In parallel experiments, spasmolytic effect of CGA was also demonstrated. In acute EtOH‐induced gastric ulceration model in rats, extract (100?mg/kg p.o.) showed significant gastroprotective effect (gastric damage score 0.50), similar to ranitidine (20?mg/kg p.o.). Obtained results showed that tested F. heuffelii polar extract represents new herbal preparation with potential use against some gastrointestinal complaints.
NSTL
Wiley
