首页|Double-dose cefuroxime concentrations in bone, synovial fluid of the knee joint and subcutaneous adipose tissue ? A randomised porcine microdialysis study
Double-dose cefuroxime concentrations in bone, synovial fluid of the knee joint and subcutaneous adipose tissue ? A randomised porcine microdialysis study
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Elsevier
This study evaluated target tissue concentrations of double dose cefuroxime administered intravenously as either one 15 min infusion of 3000 mg (Group 1) or two single 15 min infusions of 1500 mg administered 4 h apart (Group 2). Sixteen pigs were randomised into two groups of eight. Cortical and cancellous bone, synovial fluid of the knee joint and subcutaneous adipose tissue concentrations were measured based on sampling via micro dialysis. Plasma samples were collected as a reference. Comparison of the groups was based on time with concentrations above relevant minimal inhibitory concentrations (fT 0.01). Cortical bone showed a tendency towards longer fT MIC (4 ?g/mL) in Group 2 (280 min) than in Group 1 (207 min) (p = 0.053). Within 50 min after administration, the mean concentration of 4 ?g/mL was reached in all compartments for both groups. The mean concentrations decreased below 4 ?g/mL after approximately 4 h (Group 1) and 3 h (Group 2) from initiation of administration (time zero). During an 8 h interval, double-dose cefuroxime administered as 2 ? 1500 mg with a 4 h interval provides longer time above MIC breakpoint for Staphylococcus aureus (4 ?g/mL) than a single bolus of 3000 mg cefuroxime. To maintain sufficient tissue concentrations during longer surgeries, re-administration of cefuroxime (1500 mg) should be considered 3 h after the first administration.
Surgical site infectionCefuroximeMicrodialysisBone concentrationDouble-doseTarget tissue
Jorgensen, A. R.、Hanberg, P.、Bue, M.、Thomassen, M. B.、Jorgensen, N. Pedersen、Stilling, M.
展开 >
Aarhus Univ Hosp, Orthopaed Res Unit, Aarhus Microdialysis Res Grp, Aarhus N, Denmark
Aarhus Univ Hosp, Dept Infect Dis, Aarhus N, Denmark
NSTL
Elsevier
