ATP-Dependent Lon Proteases in the Cellular Protein Quality Control System
Kudzhaev, A. M. 1Andrianova, A. G. 1Gustchina, A. E. 2Smirnov, I., V 1Rotanova, T., V1
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作者信息
1. Russian Acad Sci
2. NCI
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Abstract
The Protein Quality Control (PQC) system plays a leading role in maintaining the safety of the cellular proteome in all natural kingdoms. This review summarizes information about the structural and functional characteristics of molecular chaperones and energy-dependent proteases that form the PQC system, emphasizing the crucial role of proteins belonging to the AAA(+) superfamily, with the focus on ATP-dependent Lon proteases as a special family in the PQC. Similarities and differences among the enzymes of individual Lon subfamilies are discussed in detail using up-to-date data, elucidating the structural features and unique mechanisms of functioning of these proteins.
Key words
protein quality control system/AAA(+) proteins/molecular chaperones/ATP-dependent proteolysis/Lon proteases/3D structure/cryo-EM/ESCHERICHIA-COLI LON/N-TERMINAL DOMAIN/CRYSTAL-STRUCTURE/SUBSTRATE-RECOGNITION/MOLECULAR CHAPERONES/STRUCTURAL INSIGHTS/REGULATORY PARTICLE/COMPLEX-FORMATION/CATALYTIC DOMAIN/OXIDATIVE STRESS
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