首页|Transcriptomic analysis reveals antibacterial mechanism of flavonoids from Sedum aizoon L. against Pseudomonas fragi
Transcriptomic analysis reveals antibacterial mechanism of flavonoids from Sedum aizoon L. against Pseudomonas fragi
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NSTL
Elsevier
Flavonoids in Sedum aizoon L. (FSAL) have been used traditional medicine due to its antibacterial properties and anti-inflammatory. In this study, the molecular mechanisms involved in the action of FSAL on Pseudomonas fragi (P. fragi) were investigated for the first time using the transcriptome. The results showed that FSAL treatment (1.0 MIC) disrupted the intracellular sulfate assimilation pathway and led to disturbances in glutathione redox homeostasis. A total of 298 genes were found to be responsive to FSAL, including 233 up-regulated and 65 down-regulated. The highlighted changes were those related to sulfur metabolism, ABC transporters, aminobenzoate degradation and benzoate degradation. In summary, the intervention of FSAL resulted in the disturbance of cellular metabolic processes and redox homeostasis, which inhibited P. fragi. The results revealed the mechanism of P. fragi inhibition under FSAL treatment, which could be helpful for the application of FSAL in food industry and food safety.
Flavonoids from Sedum aizoon L. (FSAL)Pseudomonas fragiAntibacterial mechanismTranscriptomeANTIMICROBIAL ACTIONSULFUR STARVATIONESCHERICHIA-COLIMEAT SPOILAGEIDENTIFICATIONPROTEINS
NSTL
Elsevier
