首页|The role of mechanosensitive Piezo1 channel in diseases

The role of mechanosensitive Piezo1 channel in diseases

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  • NSTL
  • Elsevier
? 2022 Elsevier LtdMechanotransduction is associated with organ development and homoeostasis. Piezo1 and Piezo2 are novel mechanosensitive ion channels (MSCs) in mammals. MSCs are membrane proteins that are critical for the mechanotransduction of living cells. Current studies have demonstrated that the Piezo protein family not only functions in volume regulation, cellular migration, proliferation, and apoptosis but is also important for human diseases of various systems. The complete loss of Piezo1 and Piezo2 function is fatal in the embryonic period. This review summarizes the role of Piezo1 in diseases of different systems and perspectives potential treatments related to Piezo1 for these diseases.

Genetic diseasesIon channelMechanical forcePiezo1Potential treatments

Wang X.、Cao W.、Shi C.、Zhang H.、Chen W.、Song S.、Zhang Z.

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Department of Human Anatomy Histology and Embryology School of Basic Medicine Qingdao University

Department of Cardiac Surgery The Affiliated Hospital of Qingdao University Qingdao University

Department of Urology The Affiliated Xinqiao Hospital The Third Military Medical University

School of Basic Medicine College of Medicine Qingdao University

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2022

10.1016/j.pbiomolbio.2022.04.006

Progress in Biophysics and Molecular Biology

Progress in Biophysics and Molecular Biology

ISSN：0079-6107
年,卷(期)：2022.172
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