首页|Novel phenolic and diterpenoid compounds isolated from the fruit spikes of Prunella vulgaris L. and their anti-inflammatory activities
Novel phenolic and diterpenoid compounds isolated from the fruit spikes of Prunella vulgaris L. and their anti-inflammatory activities
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NSTL
Elsevier
? 2022 Phytochemical Society of EuropeTwo novel phenolic compounds, prunellanate A (1) and prunellanate B (2), together with a diterpenoid compound, prunelladiterpenol A (3), were successfully isolated from the fruit spikes of Prunella vulgaris L. (Figure 1). Their structures were determined after extensive spectroscopic analyses including IR NMR, HR-ESI-MS empirical electronic circular dichroism (ECD), and X-ray diffraction. The biological activities of these new compounds on NO production in LPS (Lipopolysaccharide)-simulated RAW264.7 cells were evaluated. Compounds 1 and 3 showed significant anti-inflammatory activities revealing IC50 values of 6.77 and 8.61 μM, respectively (aminoguanidine as positive control, IC50 20.33 ± 1.08 μM).
Anti-inflammatory activityDiterpeneLignansPrunella vulgaris L.
Key Laboratory of Standardization of Chinese Medicines Ministry of Education Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine
NSTL
Elsevier
