首页|AIE-active fluorescent polymeric nanoparticles about dextran derivative: preparation and bioimaging application
AIE-active fluorescent polymeric nanoparticles about dextran derivative: preparation and bioimaging application
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NSTL
Taylor & Francis
Aggregation-induced emission (AIE), as a special phenomenon of fluorescence, can elegantly overcome the fluorescence quenching caused by common fluorescent materials under high concentration conditions and has attracted interest of researchers in many fields. Particularly AIE-active polymer nanoparticles have been widely utilized in a modern biomedical research. In this work, we prepared a novel kind of AIE-active fluorescent polymeric nanoparticals (Dex-OH-CHO) through a facile esterification between a new hydrophobic AIE-active 1, 8-naphthalimide derivative and the hydrophilic dextran. The structure and optical properties of Dex-OH-CHO were characterized in detail by FTIR, H-1 NMR, XPS, TEM and fluorescence spectra. The results showed that Dex-OH-CHO emitted light-blue fluorescence in aqueous solution with high fluorescent quantum yield (phi = 24.43%, concentration is 20 mu g/mL), low CMC (5 mu g/mL), good photostability, high water solubility and well dispersivity. Moreover, good biocompatibility and ideal cell uptake made Dex-OH-CHO had a great application potential in biological imaging.
NSTL
Taylor & Francis
