首页|Cryopreservation of small numbers of human spermatozoa in a Stripper tip: Report of the first live-birth worldwide

Cryopreservation of small numbers of human spermatozoa in a Stripper tip: Report of the first live-birth worldwide

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Purpose: The aim is to report the first live-birth following ICSI using spermatozoa previously vitrified in a Stripper Tip. Principal results: A 34-year-old cryptozoospermic man was enrolled in a sperm vitrification program. After failure of conventional freezing technique, spermatozoa were vitrified using two carriers: a commercially-available, Cell Sleeper, and a ?home-made? one, Stripper Tip. This man and his 30-year-old wife underwent an ICSI attempt using vitrified-warmed spermatozoa from these devices. All frozen-warmed spermatozoa were quickly recovered. Among the oocytes retrieved, six were injected with sperm from the Cell Sleeper, and seven with sperm from the Stripper tip, leading to 4 embryos in each case. Two embryos, arising from sperm frozen in the Stripper tip, were transferred, resulting in a healthy live-birth. Conclusions: This is the first successful delivery following the use of spermatozoa frozen in an original device, the Stripper Tip, giving a promising prospect for managing severe male infertilities.

CryopreservationSmall numbers of spermatozoaVitrificationStripper tipLive birth

Herbemont, Charlene、Mnallah, Sonia、Bennani-Smires, Badria、Peigne, Maeliss、Cedrin-Durnerin, Isabelle、Grynberg, Michael、Sifer, Christophe

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Hop Univ Paris Seine St Denis, AP HP, Dept Reprod Biol, F-93140 Bondy, France

Hop Univ Paris Seine St Denis, AP HP, Dept Reprod Med, F-93140 Bondy, France

2021

Cryobiology

Cryobiology

SCI
ISSN:0011-2240
年,卷(期):2021.99
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