首页|Oleanane type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao

Oleanane type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao

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  • NSTL
  • Elsevier
Astragalus membranaceus is a Traditional Chinese Medicine (TCM) belonging to the Leguminosae family. It has been used as antidiabetic, cardioprotective, and hepatoprotective in the TCM clinic. From the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, 14 oleanane type saponins (1-14) including eight new ones, astroolesaponins A (1), B (2), C-1 (3), C-2 (4), D (5), E-1 (6), E-2 (7), and F (8) were obtained, and their structures were elucidated by chemical and spectroscopic methods. Compounds 1-5, 7, 8,11, and 13 showed decreased effects on triglyceride levels in sodium oleate induced HepG2 cells. (C) 2015 Elsevier B.V. All rights reserved.

Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) HsiaoStemOleanane typeSaponinHepG2 cellsTriglyceride accumulation inhibitory effects

Zhang, Yi、Li, Xiaoxia、Ruan, Jingya、Wang, Tingting、Dong, Yongzhe、Hao, Jia、Liu, Erwei、Han, Lifeng、Wang, Tao、Gao, Xiumei

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Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, 312 Anshanxi Rd, Tianjin 300193, Peoples R China

Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, 312 Anshan Rd, Tianjin 300193, Peoples R China

2016

10.1016/j.fitote.2015.12.006

Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
年,卷(期)：2016.109
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