首页|Jatrophane polyesters from the leaves of Euphorbia peplus with anti-inflammatory activity

Jatrophane polyesters from the leaves of Euphorbia peplus with anti-inflammatory activity

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  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropeThree new jatrophane polyesters, Euphopepluanones M-O (1–3), along with eight known ones (4-11), were isolated from the leaves of Euphorbia peplus Linn. Their chemical structures were established based on extensive spectroscopic analysis. The absolute configurations of compound 1 were assigned by X-ray crystallographic analysis. In addition, their anti-inflammatory effects on lipopolysaccharide-induced RAW264.7 macrophages were evaluated in vitro. Among them, 2 and 7 exhibited significant anti-inflammatory activity.

Anti-inflammatory activityDexamethasoneDiterpenoidEuphorbia peplusEuphorbiaceaeJatrophane polyester

Hao X.-J.、Yang Y.、Cheng Y.-Y.、Ran X.、Luo R.、Li Y.-Y.、Li D.-M.、Sun M.、Lu Q.-Y.、Pu X.-X.、Wan J.-J.、Huang J.-Y.、Guan S.-P.、Di Y.-T.

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State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

International Institute for Translational Chinese Medicine School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology Chinese Academy of Sciences

College of Life Sciences Yunnan University

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2022

10.1016/j.phytol.2022.03.017

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.49
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