Ten undescribed cadinane-type sesquiterpenoids from Eupatorium chinense

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NSTL
Elsevier

外文摘要：? 2021 Elsevier B.V.Ten undescribed cadinane-type sesquiterpenes (1?10) were isolated from the whole plant of Eupatorium chinense. Their planar structures were mainly elucidated by extensive analysis of spectroscopic data and DFT NMR calculations. The absolute configurations of 1, 2, and 3 were determined by TDDFT ECD calculations while those of compounds 4–7 and 9 were confirmed by single crystal X-ray diffraction experiments. Compounds 2 and 3 are a pair of C-10 epimers, compounds 4 and 5 a pair of C-1 epimers, and compounds 9 and 10 a pair of compounds isomerized at both C-1 and C-10. A possible biosynthetic pathway for these new sesquiterpenes was proposed.

外文关键词：

CadinaneDFT NMR calculationEupatorinic acids A-DEupatorinolides A-FEupatorium chinenseTDDFT ECD calculation

作者：

Tang C.、Ye Y.、Chen Z.、Ke C.-Q.、Zhou S.、Feng L.

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作者单位：

State Key Laboratory of Drug Research and Natural Products Chemistry Department Shanghai Institute of Materia Medica Chinese Academy of Sciences

出版年：

2022

DOI：

10.1016/j.fitote.2021.105091

Fitoterapia

SCI

ISSN：0367-326X

年,卷(期)：2022.156

参考文献量37