首页|Curcumin-loaded Fe-MOF/PDMS porous scaffold: Fabrication, characterization, and biocompatibility assessment
Curcumin-loaded Fe-MOF/PDMS porous scaffold: Fabrication, characterization, and biocompatibility assessment
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NSTL
Elsevier
? 2022 The Korean Society of Industrial and Engineering ChemistryFabrication of biocompatible scaffolds that can facilitate the mending of damaged tissue has attracted much attention. In this study, the preparation and structural investigation of a curcumin-loaded Fe(II) metal–organic framework/polydimethylsiloxane sponge, Cur/Fe-MOF/PDMS, are reported. Various techniques such as FTIR (Fourier-transform infrared), XRD (X-ray diffraction), SEM (scanning electron microscope), TEM (transmission electron microscope), EDS (energy-dispersive X-ray spectroscopy) mapping, and XPS (X-ray photoelectron spectroscopy) have been used to investigate the as-fabricated materials. Results confirm the successful incorporation of curcumin and Fe-MOF into the PDMS matrix. The obtained SEM images indicate the sponge-like structures of the PDMS and the Fe-MOF/PDMS composite. Indeed, the results from in vivo show animals all to be survived without any unusual responses to the transplant. According to macroscopic observation, the Fe-MOF/PDMS and Cur/Fe-MOF/PDMS scaffolds seem better confederates than the pure PDMS. H&E staining has confirmed enhanced healing and revascularization in the Cur/Fe-MOF/PDMS than the PDMS and Fe-MOF/PDMS scaffolds. Additionally, a two-stage profile was observed for the release of curcumin into PBS (phosphate-buffered saline) solution. The hydrophilic property of the Fe-MOF resulted in fast release at the first stage. These results exhibit that the Cur/Fe-MOF/PDMS sponge can serve as a 3D porous substrate in the tissue engineering (TE) field.
NSTL
Elsevier
