首页|Nitric oxide production inhibitory activity of clerodane diterpenes from Monoon membranifolium

Nitric oxide production inhibitory activity of clerodane diterpenes from Monoon membranifolium

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  • NSTL
  • Taylor & Francis
Abstract A new clerodane diterpene, 2β-methoxyhardwickiic acid (1), and four known compounds (2–5) were isolated from the twigs of Monoon membranifolium. The structure of the new compound was determined by extensive spectroscopic methods and ESITOFMS data. The absolute configuration of 1 was established by a comparison of its ECD spectrum and specific rotation with those of related previously reported compounds. All compounds were evaluated for their nitric oxide (NO) production inhibitory activities in RAW264.7 macrophage cells. Compounds 3 and 5 inhibited NO production with IC50 values of 16.1 and 28.9?μM, respectively, which were better than that of standard compound, indomethacin (IC50 = 32.2?μM).

Monoon membranifoliumAnnonaceaeclerodane diterpenenitric oxide production inhibitory activity

Isaraporn,Polbuppha、Virayu,Suthiphasilp、Tharakorn,Maneerat、Rawiwan,Charoensup、Thunwadee,Limtharakul、Sarot,Cheenpracha、Stephen G.,Pyne、Surat,Laphookhieo

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Center of Chemical Innovation for Sustainability (CIS) and School of Science, Mae Fah Luang

Medicinal Plant Innovation Center of Mae Fah, Luang University

Department of Chemistry, Faculty of Science and Research Center on Chemistry for Development of

School of Science, University of Phayao

School of Chemistry and Molecular Bioscience, University of Wollongong

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2022

10.1080/14786419.2021.1912044

Natural product research

Natural product research

SCI
ISSN：1478-6419
年,卷(期)：2022.36(10/12)
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