Nitric oxide production inhibitory activity of clerodane diterpenes from Monoon membranifolium

Isaraporn,Polbuppha ¹Virayu,Suthiphasilp ¹Tharakorn,Maneerat ¹Rawiwan,Charoensup ²Thunwadee,Limtharakul ³Sarot,Cheenpracha ⁴Stephen G.,Pyne ⁵Surat,Laphookhieo¹

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作者信息

1. Center of Chemical Innovation for Sustainability (CIS) and School of Science, Mae Fah Luang
2. Medicinal Plant Innovation Center of Mae Fah, Luang University
3. Department of Chemistry, Faculty of Science and Research Center on Chemistry for Development of
4. School of Science, University of Phayao
5. School of Chemistry and Molecular Bioscience, University of Wollongong
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Abstract

Abstract A new clerodane diterpene, 2β-methoxyhardwickiic acid (1), and four known compounds (2–5) were isolated from the twigs of Monoon membranifolium. The structure of the new compound was determined by extensive spectroscopic methods and ESITOFMS data. The absolute configuration of 1 was established by a comparison of its ECD spectrum and specific rotation with those of related previously reported compounds. All compounds were evaluated for their nitric oxide (NO) production inhibitory activities in RAW264.7 macrophage cells. Compounds 3 and 5 inhibited NO production with IC50 values of 16.1 and 28.9?μM, respectively, which were better than that of standard compound, indomethacin (IC50 = 32.2?μM).

Key words

Monoon membranifolium/Annonaceae/clerodane diterpene/nitric oxide production inhibitory activity

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出版年

2022

Natural product research

SCI

ISSN：1478-6419

被引量2

参考文献量17

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