首页|Serum Insulin-like Growth Factors, Insulin-like Growth Factor-binding Protein-3, and Risk of Lung Cancer Death: A Case-control Study Nested in the Japan Collaborative Cohort (JACC) Study.
Serum Insulin-like Growth Factors, Insulin-like Growth Factor-binding Protein-3, and Risk of Lung Cancer Death: A Case-control Study Nested in the Japan Collaborative Cohort (JACC) Study.
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
To elucidate the roles of insulin-like growth factors (IGFs) in the development of lung cancer, we conducted a case-control study nested within the Japan Collaborative Cohort Study. Serum samples were collected at baseline from 39140 men and women between 1988 and 1990. We measured serum IGF-I, IGF-II, and IGF-binding protein-3 (IGFBP-3) in 194 case subjects who subsequently died from lung cancer during an 8-year follow-up and in 9351 controls. The odds ratios (ORs), adjusted for smoking and other covariates, were smaller with higher levels of IGF-II and IGFBP-3. The ORs across quartiles were 0.41 (95% confidence interval [CI], 0.27 - 0.63), 0.47 (0.31 - 0.71), and 0.67 (0.46 - 0.98) for IGF-II (trend P = 0.018), and 0.55 (95% CI, 0.37 - 0.81), 0.54 (0.36 - 0.82), and 0.67 (0.45 - 1.01) for IGFBP-3 (trend P = 0.037). These peptides were not independently related to lung cancer risk when mutually adjusted. The risk was increased in the highest vs. the lowest quartile of IGF-I only after controlling for
Malignant neoplasm of lungInsulin-Like Growth Factor Binding Protein 3胰岛素样生长因子结合蛋白质3危险胰岛素样生长因子Ⅱ生长物质
Department of Preventive Medicine / Biostatistics and Medical Decision Making Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan. wakai@med.nagoya-u.ac.jp
NSTL
