Weak Bronsted base-promoted photoredox catalysis for C-H alkylation of heteroarenes mediated by triplet excited diaryl ketone
Li, Lifan 1Song, Xuyan 2Qi, Mei-Fang 1Sun, Bing1
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作者信息
1. Wuhan Univ Technol
2. China Tobacco Hubei Ind LLC
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Abstract
A weak Bronsted base-promoted photoredox catalysis has been developed for the direct C-H alpha-alkyla-tion of heteroarenes with cyclic and acyclic ethers. The high efficiency of this strategy is demonstrated by the mild reaction conditions, broad substrate scope, economical reagents and high regioselectivity. With air as the sole oxidant, a set of alkylated heteroarenes were accessed smoothly. This strategy was also applied for late-stage functionalization of valuable vitamin E nicotinate and loratadine. (C) 2022 Elsevier Ltd. All rights reserved.
NSTL
Elsevier