首页|Copper in tumors and the use of copper-based compounds in cancer treatment

Copper in tumors and the use of copper-based compounds in cancer treatment

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  • NSTL
  • Elsevier
Copper homeostasis is strictly regulated by protein transporters and chaperones, to allow its correct distribution and avoid uncontrolled redox reactions. Several studies address copper as involved in cancer development and spreading (epithelial to mesenchymal transition, angiogenesis). However, being endogenous and displaying a tremendous potential to generate free radicals, copper is a perfect candidate, once opportunely complexed, to be used as a drug in cancer therapy with low adverse effects. Copper ions can be modulated by the organic counterpart, after complexed to their metalcore, either in redox potential or geometry and consequently reactivity. During the last four decades, many copper complexes were studied regarding their reactivity toward cancer cells, and many of them could be a drug choice for phase II and III in cancer therapy. Also, there is promising evidence of using 64Cu in nanoparticles as radiopharmaceuticals for both positron emission tomography (PET) imaging and treatment of hypoxic tumors. However, few compounds have gone beyond testing in animal models, and none of them got the status of a drug for cancer chemotherapy. The main challenge is their solubility in physiological buffers and their different and non-predictable mechanism of action. Moreover, it is difficult to rationalize a structure-based activity for drug design and delivery. In this review, we describe the role

CancerCopper in cancerCancer therapyCopper complexes copper in medicineRadiotherapyCopper in tumorANTICANCER DRUG CISPLATINCOMPLEXES CRYSTAL-STRUCTURESTRANSITION-METAL-COMPLEXESRADIO-PHOTOTHERMAL THERAPYALPHA-KETOGLUTARIC ACIDL1210 MURINE LEUKEMIAPHASE-II TRIALSCHIFF-BASEIN-VITROOXIDATIVE STRESS

da Silva, Daniela Almeida、De Luca, Anastasia、Squitti, Rosanna、Rongioletti, Mauro、Rossi, Luisa、Machado, Camila M. L.、Cerchiaro, Giselle

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Fed Univ ABC UFABC

Univ Roma Tor Vergata

IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell

San Giovanni Calibita Fatebenefratelli Hosp

Univ Sao Paulo

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2022

10.1016/j.jinorgbio.2021.111634

Journal of Inorganic Biochemistry

Journal of Inorganic Biochemistry

ISTP
ISSN：0162-0134
年,卷(期)：2022.226
  • 43
  • 303