首页|Chemical Constituents of Dactylicapnos torulosa and Their Antithrombotic Activities
Chemical Constituents of Dactylicapnos torulosa and Their Antithrombotic Activities
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NSTL
Elsevier
? 2022Dactylicapnos torulosa (D. torulosa) has been traditionally used as a therapeutic remedy. Here, a combined strategy using both phytochemical and biological approaches was conducted to discern the effective components of D. torulosa. Three new alkaloids, namely, (1–3), Torulosine A, 1-Methoxypseudoprotopine and 1,14-Dimethoxyprechilenine together with 33 (4–36) known compounds were isolated. The structures of the new compounds were fully established by extensive analysis of HR-ESI-MS NMR and CD spectroscopic data. These compounds were then screened using zebrafish bioassay methods for antithrombotic activities. Compounds 5 and 7 had the best antithrombotic effect with prevention rates of 100% at 50 μM, and Compounds 8, 4, 9 and 11 at 50 μM had prevention rates of 81.3%, 79.4%, 84.4% and 79.3%, respectively. The antithrombotic effect of compounds may be related to their inhibitory effect on platelet aggregation. The present study contributes to the diverse chemical and bioactivity data of the Dactylicapnos genus.
Department of Natural Product Chemistry Key Laboratory of Chemical Biology (Ministry of Education) School of Pharmaceutical Sciences Cheeloo College of Medicine Shandong University
Biology Institute Qilu University of Technology (Shandong Academy of Sciences)
NSTL
Elsevier
