首页|Two new polyhydroxylated steroidal glycosides from Paris polyphylla var. yunnanensis
Two new polyhydroxylated steroidal glycosides from Paris polyphylla var. yunnanensis
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NSTL
Elsevier
? 2022 Phytochemical Society of EuropeChemical investigation of Paris polyphylla smith var. yunnanensis afforded two new polyhydroxylated steroidal glycosides, named Parisyunnanosides K and L (1–2), together with nine known ones. The chemical structures of the new compounds were elucidated by 1D, 2D NMR and HR-ESI-MS techniques, together with chemical methods. Parisyunnanosides K and L (1–2) are rare C27 steroidal glycosides with two double bonds located at C-5, 6 and C-25, 26 of the aglycone, respectively. The cytotoxic activities of the isolated compounds were evaluated against Caco-2 cells by CCK-8 assay. Among them, compounds 5–11 exhibited potent cytotoxic activity with IC50 values ranging from 1.10 to 14.14 μM compared with the positive control oxaliplatin (1.38 μM).
C27 Steroidal glycosidesCytotoxic activityParis polyphylla var. YunnanensisParisyunnanosides K and L
Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of Biology Chinese Academy of Sciences
University of Chinese Academy of Sciences
Engineering Research Center for Pharmaceuticals and Equipments of Sichuan Province Sichuan Industrial Institute of Antibiotics School of Pharmacy Chengdu University
NSTL
Elsevier
